About Us

Photo courtesy of Cincinnati Children's Hospital Medical CenterThe Pediatric Early Phase-Clinical Trial Network (PEP-CTN) is comprised of 21 premier Children Oncology Group (COG) pediatric core member sites in the U.S. and 21 non-core member sites in the U.S., Canada and Australia that were selected through a peer review process. The PEP-CTN builds on the strengths and accomplishments of the COG Phase 1/Pilot Consortium to effectively and efficiently conduct state-of-the-art early phase trials. The PEP-CTN will leverage collaborative interaction with COG disease committees, COG leadership, NCI leadership, and the pharmaceutical industry to prioritize and streamline the development of new, targeted therapies for children with cancer. Innovative trial design and endpoints, genomic biomarkers and other correlative studies will augment the impact of PEP-CTN trials on individual patients and drug development for childhood cancer.

The PEP-CTN successfully leverages the database infrastructure and resources of the parent COG while maintaining its own administrative and operational infrastructure to ensure rapid development, implementation and reporting of specialized and complex early phase clinical trials. The PEP-CTN has expert resources for the conduct of translational biology, pharmacokinetic, and pharmacogenetics studies, and has developed a state-of-the art infrastructure to facilitate image transfer of specialized correlative imaging studies for central review and analyses.

Dr. Brenda J. Weigel, MD
University of Minnesota Medical Center-Fairview
Department of Pediatrics, Hem/Onc/BMT
420 Delaware Street, SE
MMC 366
Minneapolis, MN 55455
Tel: (612) 626-5501
Fax: (612) 624-3913
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

PEP-CTN Vice-Chair
Dr. Elizabeth Fox, MD
Saint Jude Children's Research Hospital
Cancer Center; Clinical Trials Administration
262 Danny Thomas Place
MS 274
Memphis, TN  38105
Tel: (901) 595-1994
Fax: (901) 595-7031
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

PEP-CTN Operations Data/Statistics Center
Children's Oncology Group
1333 S. Mayflower Avenue, Suite 260
Monrovia, CA 91016
Tel: (626) 241-1500
Fax: (626) 445-4334


© The Children's Oncology Group
The information and content provided on this website is made available for informational purposes only for children and their families affected by cancer. While the Children's Oncology Group strives to provide accurate and up-to-date information, the information may be out of date or incomplete in certain respects. Please do not rely on this information and seek the care of a qualified medical professional if you have questions regarding a specific medical condition, disease, diagnosis or symptom. The information and content presented herein is not intended to replace the independent clinical judgement, medical advice, screening, health counseling, or other intervention performed by your (or your child's) health care provider. Please contact "911" or your emergency services if this is a health emergency. No endorsement of any specific tests, products, or procedures is made herein.