Children’s Oncology Group (COG)

Who We Are

The Children’s Oncology Group (COG) is the world’s largest, cooperative children’s cancer research entity. It brings together treatment centers, physicians, laboratory scientists, nurses, psychologists and others working to beat cancer in children, adolescents and young adults. Through collaborative research, the Children’s Oncology Group has improved rates for children’s cancer at a pace much faster than any one individual or single institution could accomplish alone. The Children’s Oncology Group research has turned children’s cancer from a virtually incurable disease 40 years ago to one with an overall cure rate of 78 percent today.

Despite major advancements in recent years, much work remains to find treatments and cures for children’s cancer. Cancer remains the leading cause of death by disease in children and two-thirds of patients have life-altering and life-threatening side effects from the currently available treatments. Children’s Oncology Group research efforts are focused on many types of cancer including those that are hardest to treat, as well as reducing complications that result from treatment.

The Children’s Oncology Group is chaired by Peter Adamson, MD. Dr. Adamson is Chief of the Division of Clinical Pharmacology & Therapeutics and Director of the Office of Clinical and Translational Research at The Children's Hospital of Philadelphia. Susan Blaney, MD is vice chair of the Children’s Oncology Group. Dr. Blaney is Vice Chair for Research in the Department of Pediatrics at Baylor College of Medicine and Deputy Director of Texas Children's Cancer and Hematology Centers.

What We Do

Children’s Oncology Group:

  • designs and conducts about 100 clinical trials annually to find the best treatments for children and adolescents with cancer;
  • conducts laboratory research that will translate into more effective treatments with reduced side effects;
  • looks for the causes of childhood cancer with the goal of one day preventing cancer;
  • conducts research to improve quality of life and survivorship; and
  • seeks international partnerships, when necessary, to fulfill its mission.

Our History

Children’s Oncology Group was formed in 2000 when four pediatric cancer clinical trials groups joined forces. Comprised of 210 treatment centers in North America, Europe, Australia, New Zealand and South Africa, COG includes more than 6,500 individual members. The COG receives funding from the national non-profit foundation, CureSearch for Children’s Cancer which receives grants from the National Cancer Institute and raises funds through philanthropic donations from individuals, special events, corporations and private foundations.

Children’s Oncology Group hospitals treat 90 percent of children with cancer in the United States, providing the unmatched combination of global expertise and local care. This means that every child and care team has complete access to the latest research and world-class treatments at hospitals within close to home.

Why is Collaborative Research Important?

While nearly 13,500 children and adolescents are diagnosed with cancer each year, there are many different kinds of children’s cancer. When divided into the specific cancer types, the number of children with each is relatively small. In research, large numbers of patients are critical to ensuring that study results are meaningful. By enrolling patients from many hospitals in the same trial, the results become statistically significant. This approach is called collaborative research and is how the Children’s Oncology Group functions.

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